Human-Specific Endogenous Retroviruses
نویسندگان
چکیده
منابع مشابه
Human endogenous retroviruses and cancer
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control or deactivating mutations. However, a correlation between HERVs and human cancer has been described and many tumors, such as melanoma, brea...
متن کاملEndogenous Retroviruses and Human Evolution
Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could be caused by inherited changes in regulatory systems. Endogenous retroviruses (ERVs) comprise approximately 5% of the human genome. The LTRs of ERVs contain many regulatory sequences, such as promoters, enhancers, polyadenylation sign...
متن کاملNewly identified families of human endogenous retroviruses.
Human endogenous retroviruses (HERVs) make up approximately 8.3% of the human genome (12). HERVs have previously been classified into 31 distinct families based upon sequence alignment of reverse transcriptase (RT) and envelope domains and subsequent phylogenetic analyses (1, 9, 16). Using the data mining program LTR_STRUC (13) in conjunction with conventional sequence homology techniques, we r...
متن کاملHERVd: database of human endogenous retroviruses
The human endogenous retroviruses database (HERVd) is maintained at the Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, and is accessible via the World Wide Web at http://herv.img.cas.cz. The HERVd provides complex information on and analysis of retroviral elements found in the human genome. It can be used for searches of individual HERV families, identification of H...
متن کاملHERVd: the Human Endogenous RetroViruses Database: update
An elaboration of HERVd (http://herv.img.cas.cz) is being carried out in two directions. One of them is the integration and better classification of families that diverge considerably from typical retroviral genomes. This leads to a more precise identification of members with individual families. The second improvement is better accessibility of the database and connection with human genome ann...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2007
ISSN: 1537-744X
DOI: 10.1100/tsw.2007.270